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USP DI Vol. II - DAPIPRAZOLE (Ophthalmic)

DAPIPRAZOLE (Ophthalmic)


Some commonly used brand names are:

In the U.S.?

  • Rev-Eyes

In Canada?

  • Rev-Eyes

Category

  • Antimydriatic

Description

Dapiprazole (da-PI-pray-zole) is used in the eye to reduce the size ofthe pupil after certain kinds of eye examinations.

Some eye examinations are best done when your pupil (the black center ofthe colored part of your eye) is very large, so the doctor can see into youreye better. This medicine helps to reduce the size of your pupil back to itsnormal size after the eye examination.

Dapiprazole is available in the following dosage form:

    Ophthalmic
  • Ophthalmic solution (eye drops) (U.S. and Canada)


Before Using This Medicine

In deciding to use a medicine,the risks of using the medicine must be weighed against the good it will do.This is a decision you and your doctor will make. For dapiprazole, the followingshould be considered:

Allergies?Tell your doctor if you have ever had any unusual orallergic reaction to dapiprazole. Also tell your health care professionalif you are allergic to any other substances, such as foods, preservatives,or dyes.

Pregnancy?Dapiprazole has not been studied in pregnant women.However, dapiprazole has not been shown to cause birth defects or other problemsin animal studies.

Breast-feeding?It is not known whether dapiprazole passes intothe breast milk. However, this medicine has not been reported to cause problemsin nursing babies.

Children?Studies on this medicine have been done only in adultpatients, and there is no specific information comparing use of dapiprazolein children with use in other age groups.

Older adults?Many medicines have not been studied specificallyin older people. Therefore, it may not be known whether they work exactlythe same way they do in younger adults. Although there is no specific informationcomparing use of dapiprazole in the elderly with use in other age groups,this medicine is not expected to cause different side effects or problemsin older people than it does in younger adults.

Other medicines?Although certain medicines should not be usedtogether at all, in other cases two different medicines may be used togethereven if an interaction might occur. In these cases, your doctor may want tochange the dose, or other precautions may be necessary. Tell your health careprofessional if you are using any other ophthalmic (eye) prescription or nonprescription(over-the-counter [OTC]) medicine.

Other medical problems?The presence of other medicalproblems may affect the use of dapiprazole. Make sure you tell your doctorif you have any other medical problems, especially:

  • Eye problems, other?Use of dapiprazole may make the conditionworse

Proper Use of This Medicine

Dosing?The dose of dapiprazole will be different for different patients. Follow your doctor's orders or the directions on thelabel. The following information includes only the average doses ofdapiprazole. If your dose is different. do not changeit unless your doctor tells you to do so.

  • For ophthalmic solution (eye drops) dosageform:
    • For reduction of size of pupil of eye:
      • Adults?One drop, then one drop in five minutes, following eyeexamination.
      • Children?Use and dose must be determined by your doctor.

Precautions While Using This Medicine

Even afterusing this medicine, you may have blurred vision or other vision problems.If any of these occur, do not drive, use machines, ordo anything else that could be dangerous if you are not able to see well.

This medicine may cause your eyes to become more sensitive to light thanthey are normally. Wearing sunglasses and avoiding too much exposure to brightlight may help lessen the discomfort.


Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects.Although not all of these side effects may occur, if they do occur they mayneed medical attention.

Check with your doctor as soon as possible if any ofthe following side effects occur:

    Less common

      Irritation (severe) or swelling of the clear part of the eye

Other side effects may occur that usually do not need medical attention.These side effects may go away during treatment as your body adjusts to themedicine. However, check with your doctor if any of the following side effectscontinue or are bothersome:

    More common

      Burning of eye when medicine is applied; redness of the white part of the eye

    Less common

      Blurring of vision; browache; drooping of upper eyelid; dryness ofeye; headache; increasedsensitivity of eye to light; itching of eye; redness of eyelid; swelling of eyelid; swelling of the membrane covering the white partof the eye; tearing of eye

Other side effects not listed above may also occur insome patients. If you notice any other effects, check with your doctor.


Revised: 08/16/1993