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H2 Receptor antagonists poisoning

Definition

H2 receptor antagonist poisoning is an overdose of a medication typically used for reducing stomach acid.

Alternative Names

Cimetidine; Tagamet; Ranitidine; Zantac; Famotidine, Pepcid; Nizatidine; Axid

Poisonous Ingredient

  • Cimetidine
  • Ranitidine
  • Famotidine
  • Nizatidine

Note: This list may not be all inclusive.

Where Found

H2 receptor antagonist medications are available over-the-counter and by prescription.
  • Cimetidine (Tagamet)
  • Ranitidine (Zantac)
  • Famotidine (Pepcid)
  • Nizatidine (Axid)
Note: This list may not be all inclusive.

Symptoms

  • Abnormal heartbeat
  • Confusion
  • Diarrhea
  • Difficulty breathing
  • Drowsiness
  • Flushing
  • Low blood pressure
  • Nausea
  • Rapid heartbeat or slow heartbeat
  • Slurred speech
  • Sweating
  • Tremors
  • Vomiting
  • Walking problems

Home Care

Seek immediate medical attention. DO NOT try to make the person vomit.

Before Calling Emergency

Determine the following information:

  • Patient's age, weight, and condition
  • The name of the product (ingredients and strengths if known)
  • When it was swallowed
  • The amount swallowed

Poison Control

The National Poison Control Center (1-800-222-1222) can be called from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the U.S. use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

What to Expect at the Emergency Room

The patient may be given the following:

  • Activated charcoal
  • Laxative
  • Other medicines to treat symptoms

Some or all of the following procedures may be performed:

  • Stomach emptying (gastric lavage)
  • Artificial respiration (breathing) if necessary

Outlook (Prognosis)

Serious complications are rare.

References

Morgan JC. Drug-induced tremors. Lancet Neurol. 2005; 4(12): 866-76.

Feldman M, Friedman LS, Sleisenger MH, eds. Sleisenger & Fordtran?s Gastrointestinal and Liver Disease. 7th ed. Philadelphia, Pa: WB Saunders; 2002: 759.


Review Date: 2/13/2006
Reviewed By: Stephen C Acosta, MD, Department of Emergency Medicine, Portland VA MedicalCenter, Portland, OR. Review provided by VeriMed Healthcare Network.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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