Hepatic vein obstruction (Budd-Chiari)
Definition
Hepatic vein obstruction refers to a blockage of the hepatic vein, which carries blood away from the liver.
Alternative Names
Budd-Chiari syndrome; Hepatic veno-occlusive disease
Causes
Hepatic vein obstruction prevents blood from flowing out of the liver and back to the heart. This blockage can cause liver damage. Obstruction of this vein can be caused by masses pressing on the vessel (tumor) or by thrombus (clot) formation within the vessel.
Most often, it is caused by conditions that increase the body's propensity to form blood clots. These include:
- Any of a number of hereditary or acquired clotting abnormalities
- Myeloproliferative disorders -- abnormal proliferation of cells from the bone marrow
- Chronic inflammatory or autoimmune diseases
- Cancers
- Oral contraceptives and pregnancy
- Infections
Symptoms
- Right-sided abdominal pain and a large liver
- Jaundice (yellowing of the skin)
- Ascites (swelling of the abdomen due to the development of fluid in the abdomen)
- Vomiting blood
Exams and Tests
Treatment
Treatment varies, depending on the cause of the obstruction, and may include the following:
- Medical therapy for symptoms
- Anticoagulation medications
- Surgical interventions
- Radiological procedures
Possible Complications
Hepatic vein obstruction can progress to liver failure, which can be fatal.
When to Contact a Medical Professional
Call your health care provider if you have symptoms of hepatic vein obstruction or if you are undergoing treatment and any new symptoms develop.
Review Date:
7/25/2006
Reviewed By:
Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-TorresdaleHospital, Jefferson Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
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